The 2022 Mercedes-Benz GLE 350 is a midsize luxury SUV that balances refined interior craftsmanship with a composed, comfort-oriented driving experience. While it serves as the entry-level trim in the GLE lineup, it offers the same high-end MBUX infotainment system and premium materials found in higher-tier models, making it a sophisticated choice for families and executive commuters.
As we look at the 2022 Mercedes-Benz GLE 350 from the perspective of 2026, this vehicle has transitioned from a showroom centerpiece to a highly sought-after pre-owned luxury SUV. Belonging to the "W167" fourth generation, the 2022 model year remains a pivotal point for the nameplate. It preceded the mid-cycle refresh of 2024, meaning it carries the original, sleeker aesthetic of the current body style while benefiting from three years of production refinements to its software and mechanical assembly.
This review provides an in-depth analysis of the 2022 GLE 350’s performance, interior technology, practical utility, and long-term value. Whether you are evaluating a certified pre-owned (CPO) unit or assessing the vehicle’s current market standing, understanding the nuances of this specific year is essential for an informed decision.
The Heart of the GLE 350: Engine and Performance
The "350" nomenclature in 2022 signifies the use of Mercedes-Benz’s M264 engine. This is a 2.0-liter turbocharged inline-4 cylinder powerplant. For many enthusiasts of the brand, the idea of a four-cylinder engine in a large, heavy SUV was initially met with skepticism. However, the engineering behind this unit is focused on maximizing low-end torque to move the vehicle's significant curb weight (approximately 4,700 to 4,800 lbs) efficiently.
Powertrain Specifications
The engine produces 255 horsepower and 273 lb-ft of torque. It is paired exclusively with the 9G-TRONIC 9-speed automatic transmission. This transmission is a highlight of the driving experience, utilizing a wide spread of ratios to keep the engine in its optimal power band. At highway speeds, the ninth gear allows the engine to hum at low RPMs, significantly reducing cabin noise and improving fuel economy.
One critical distinction for the 2022 model year is the drivetrain configuration. The GLE 350 was available in two versions:
- GLE 350 (Rear-Wheel Drive): The standard configuration, primarily found in warmer climates. It offers a slightly tighter turning radius and marginally better fuel efficiency.
- GLE 350 4MATIC (All-Wheel Drive): This version employs Mercedes' permanent all-wheel-drive system. It can send up to 100% of torque to either the front or rear axle depending on traction needs, making it the preferred choice for regions with snow or heavy rain.
Driving Dynamics and Suspension
The 2022 GLE 350 was engineered for comfort rather than aggressive cornering. The standard suspension setup uses steel springs with selective damping. While it lacks the fancy "E-Active Body Control" hydropneumatic system found on the GLE 450 or 580, the standard setup is arguably more reliable for long-term owners in 2026, as it avoids the complexity and high repair costs of air-based systems.
On the road, the GLE 350 feels substantial. The steering is light at low speeds, facilitating easy parking, but weights up slightly on the highway. Acceleration from 0 to 60 mph takes roughly 7.1 seconds. While this is not "fast" by modern luxury standards, the delivery of power is smooth and linear, which aligns with the vehicle's "executive cruiser" persona.
Interior Excellence and MBUX Technology
If the engine is the pragmatic part of the GLE 350, the interior is where the Mercedes-Benz "luxury" promise is fully realized. The cabin of the 2022 model remains a benchmark for material quality and ergonomic design.
The Dual-Screen Dashboard
The centerpiece of the 2022 GLE 350 is the dual 12.3-inch display architecture. These two screens are housed under a single continuous glass pane, creating a widescreen "surfboard" effect across the dashboard.
- The Instrument Cluster: Highly customizable, allowing the driver to choose between "Classic," "Sport," "Progressive," and "Understated" themes. You can display full-screen navigation, trip data, or driver assistance status.
- The Infotainment Screen: This runs the Mercedes-Benz User Experience (MBUX). In 2022, this system featured advanced voice control activated by saying "Hey Mercedes." It supports Apple CarPlay and Android Auto (though in this model year, these were wired connections rather than wireless).
Material Quality and Seating
Mercedes-Benz utilized "MB-Tex" as the standard upholstery in the 2022 GLE 350. MB-Tex is a high-grade synthetic leather that is often preferred by pre-owned buyers in 2026 because it is exceptionally durable and resistant to cracking compared to genuine leather. However, many units were optioned with genuine leather or the ultra-premium Nappa leather.
The seating comfort is exemplary. The front seats are multi-contour with standard heating. Ventilation and massage functions were popular options. In the rear, the GLE offers massive legroom—nearly 41 inches—which surpasses many of its rivals in the midsize segment.
The Third-Row Option
The 2022 GLE 350 could be equipped with an optional third-row seat. It is important to note that this third row is quite cramped and is intended only for occasional use by children. Opting for the third row also adds power-adjustable second-row seats, which is a nice convenience feature even if you rarely use the way-back seats.
2022 Mercedes-Benz GLE 350 Technical Specifications
The following table summarizes the key technical data for the 2022 GLE 350 and GLE 350 4MATIC.
| Feature | GLE 350 (RWD) | GLE 350 4MATIC (AWD) |
|---|---|---|
| Engine Type | 2.0L Turbocharged Inline-4 | 2.0L Turbocharged Inline-4 |
| Horsepower | 255 hp @ 5,800-6,100 rpm | 255 hp @ 5,800-6,100 rpm |
| Torque | 273 lb-ft @ 1,800-4,000 rpm | 273 lb-ft @ 1,800-4,000 rpm |
| Transmission | 9G-TRONIC 9-Speed Automatic | 9G-TRONIC 9-Speed Automatic |
| 0-60 MPH | 7.0 Seconds | 7.1 Seconds |
| Fuel Economy (EPA Est.) | 19 City / 27 Hwy / 22 Combined | 19 City / 26 Hwy / 22 Combined |
| Fuel Tank Capacity | 22.5 Gallons | 22.5 Gallons |
| Max Towing Capacity | 7,700 lbs | 7,700 lbs |
| Cargo Space (Rear Seats Up) | 33.3 Cubic Feet | 33.3 Cubic Feet |
| Cargo Space (Max) | 74.9 Cubic Feet | 74.9 Cubic Feet |
Safety Systems and Driver Assistance
Safety has always been a pillar for Mercedes-Benz, and the 2022 GLE 350 was a Top Safety Pick+ recipient from the IIHS (Insurance Institute for Highway Safety). In 2026, these safety features remain highly relevant and competitive.
Standard Safety Features
Every 2022 GLE 350 left the factory with:
- Active Brake Assist: Radar-based technology that can alert the driver of a collision and apply brakes automatically.
- Blind Spot Assist: Essential for an SUV of this size, monitoring adjacent lanes.
- PRE-SAFE: A system that detects an imminent collision and prepares the cabin by tightening seatbelts, closing windows, and emitting a "pink noise" to protect occupants' hearing from the sound of the crash.
- ATTENTION ASSIST: Monitors driver behavior for signs of fatigue on long trips.
The Driver Assistance Package Plus
Many 2022 models were equipped with this optional package, which is highly recommended for used car buyers. It includes Active Distance Assist DISTRONIC (adaptive cruise control with stop-and-go capability) and Active Steering Assist. In 2026, this level of semi-autonomous driving is the standard expectation for luxury vehicles, and the GLE's implementation is one of the smoothest in the industry, avoiding the "ping-ponging" between lanes found in lesser systems.
Long-Term Considerations for 2026 Buyers
As the 2022 GLE 350 enters the four-year-old mark in 2026, certain ownership factors become more prominent. Unlike the GLE 450 of the same year, which utilized a 48-volt mild-hybrid system (M256 engine), the GLE 350 stuck to a traditional 12-volt architecture. This is a significant detail for long-term reliability.
Reliability and Maintenance
The 2.0L turbocharged engine is a mature design. While it is generally reliable, prospective owners should verify the service history for oil changes and spark plug replacements.
- Tires: The GLE 350 often comes with 19-inch or 20-inch wheels. Owners should budget for high-quality tires, as the vehicle's weight can lead to faster tread wear if the alignment is not maintained.
- Brakes: Given the SUV's weight, brake pads and rotors may require replacement every 30,000 to 40,000 miles depending on driving style.
- Software: Ensure the MBUX system has received its over-the-air (OTA) updates to keep the navigation and connectivity features running smoothly in 2026.
Fuel Requirements
The 2022 GLE 350 requires Premium Unleaded (91 octane or higher) fuel. Using lower-grade fuel can lead to engine knocking and reduced performance over time, which is a critical consideration for the total cost of ownership.
Pros and Cons of the 2022 GLE 350
Pros
- Interior Ambience: The lighting, materials, and screen layout remain futuristic and high-end.
- Towing Capability: Despite the four-cylinder engine, it can tow up to 7,700 lbs when properly equipped, which is best-in-class for a four-cylinder SUV.
- Quiet Cabin: Exceptional sound insulation makes it an ideal vehicle for long-distance travel.
- Cargo Versatility: The 40/20/40 split-folding rear seats allow for flexible loading of long items like skis or lumber while still carrying passengers.
Cons
- Engine Sound: Under heavy acceleration, the four-cylinder engine can sound somewhat unrefined compared to the silky inline-six of the GLE 450.
- Touchpad Controller: While the MBUX system is great, the center console touchpad can be overly sensitive and distracting for some drivers.
- Limited Third Row: As mentioned, the optional third row is essentially for emergency use only.
Frequently Asked Questions
Does the 2022 GLE 350 have wireless Apple CarPlay?
No, the 2022 GLE 350 requires a USB-C cable for Apple CarPlay and Android Auto integration. While wireless adapters are available in the aftermarket in 2026, the factory system was wired-only for this specific year.
Is the 2.0L engine powerful enough for the GLE?
For daily commuting, school runs, and highway cruising, the 2.0L engine is perfectly adequate. It delivers peak torque early in the rev range, which makes the vehicle feel responsive in city traffic. However, if you frequently drive in mountainous terrain or carry a full load of five passengers and luggage, you might find the engine working harder than a larger displacement unit would.
How does the 2022 GLE 350 compare to the BMW X5 sDrive40i?
The 2022 BMW X5 sDrive40i uses a 3.0L inline-six engine as its base, which is more powerful and smoother than the GLE 350’s four-cylinder. However, many buyers prefer the Mercedes for its more modern-looking interior and the MBUX voice interface. The BMW is generally considered the "driver's car," while the GLE 350 is the "luxury cruiser."
What are the most common issues with a used 2022 GLE 350?
Common reported issues include minor software glitches in the MBUX system and occasional sensor errors with the parking assist. Mechanically, the 2022 model is considered more robust than the earlier 2020 models, which were the first of the new generation.
Final Recommendation
The 2022 Mercedes-Benz GLE 350 remains a formidable contender in the luxury SUV market in 2026. It is best suited for those who prioritize interior luxury, safety technology, and brand prestige over raw engine performance. Because it lacks the complex 48V hybrid system of its more powerful siblings, it often represents a "safer" long-term bet for those buying in the secondary market.
If you are looking for a vehicle that provides a serene environment for the daily grind and has the capability to handle a family road trip with ease, the 2022 GLE 350 is an excellent choice. Prospective buyers should prioritize vehicles with the Driver Assistance Package Plus and a documented service history at an authorized Mercedes-Benz center.
